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英文名稱Anti-APBA1/FITC
中文名稱:FITC標記的β淀粉樣前體蛋白結合蛋白1抗體（X11α）
別 名Adapter protein X11 alpha; Adapter protein X11alpha; Amyloid beta A4 precursor protein-binding family A member 1; Apba1; APBA1_HUMAN; Mint 1; Mint-1; Neuron specific X11 protein; Neuron-specific X11 protein; Neuronal Munc18 1 interacting protein 1; Neuronal Munc18-1-interacting protein 1; UROP11; x11; X11alpha.
規格:100ul
說 明 書100ul
研究領域細胞生物 神經生物學 Alzheimer's
抗體來源Rabbit
克隆類型Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
產品應用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量93kDa
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human APBA1
亞 型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹background:
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11? (also designated Mint 1), X11Beta (Mint 2) and X11(Mint 3).
Function:
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
Subunit:
Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Binds to the cytoplasmic domain of amyloid protein (APP). Interacts (via PDZ 1 and 2 domains) with FSPB.
Subcellular Location:
Nucleus.
Tissue Specificity:
Brain and spinal cord.
Similarity:
Contains 2 PDZ (DHR) domains.
Contains 1 PID domain.
中文名稱:FITC標記的β淀粉樣前體蛋白結合蛋白1抗體（X11α）
別 名Adapter protein X11 alpha; Adapter protein X11alpha; Amyloid beta A4 precursor protein-binding family A member 1; Apba1; APBA1_HUMAN; Mint 1; Mint-1; Neuron specific X11 protein; Neuron-specific X11 protein; Neuronal Munc18 1 interacting protein 1; Neuronal Munc18-1-interacting protein 1; UROP11; x11; X11alpha.
詳細介紹：
規格:100ul
說 明 書100ul
研究領域細胞生物 神經生物學 Alzheimer's
抗體來源Rabbit
克隆類型Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
產品應用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量93kDa
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human APBA1
亞 型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資料：
產品介紹background:
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11? (also designated Mint 1), X11Beta (Mint 2) and X11(Mint 3).
Function:
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
Subunit:
Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Binds to the cytoplasmic domain of amyloid protein (APP). Interacts (via PDZ 1 and 2 domains) with FSPB.
Subcellular Location:
Nucleus.
Tissue Specificity:
Brain and spinal cord.
Similarity:
Contains 2 PDZ (DHR) domains.
Contains 1 PID domain.
