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英文名稱Anti-ABLIM1/FITC
中文名稱:FITC標記的肌動蛋白結合蛋白1抗體
別 名ABLIM 1; ABLIM; abLIM-1; ABLIM-L; ABLIM-M; ABLIM-S; ABLIM1; ABLM1_HUMAN; Actin binding double zinc finger protein; Actin binding LIM protein 1; Actin binding LIM protein family member 1; Actin-binding double zinc finger protein; Actin-binding double zinc finger protein; Actin-binding LIM protein 1; Actin-binding LIM protein family member 1; DKFZp781D0148; FLJ14564; KIAA0059; LIM actin binding protein 1; LIMAB 1; LIMAB1; Limatin; RGD1565768; RP11-317F20.1.
規格:100ul
說 明 書100ul
研究領域細胞生物 神經生物學 信號轉導 細胞骨架 細胞外基質
抗體來源Rabbit
克隆類型Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
產品應用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88kDa
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ABLIM1
亞 型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹background:
The C. elegans protein Unc-115 mediates axon guidance by modulating the growth cone Actin cytoskeleton in response to signals received by growth cone receptors. The mammalian homolog of Unc-115 is the Actin-binding LIM protein family member 1 (ABLIM1, also designated Limatin). The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription
Function:
May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.
Subunit:
Binds F-actin. Interacts with ABRA.
Subcellular Location:
Cytoplasm. Cytoplasm > cytoskeleton. Associated with the cytoskeleton.
Tissue Specificity:
Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.
Similarity:
Contains 1 HP (headpiece) domain.
Contains 4 LIM zinc-binding domains.
中文名稱:FITC標記的肌動蛋白結合蛋白1抗體
別 名ABLIM 1; ABLIM; abLIM-1; ABLIM-L; ABLIM-M; ABLIM-S; ABLIM1; ABLM1_HUMAN; Actin binding double zinc finger protein; Actin binding LIM protein 1; Actin binding LIM protein family member 1; Actin-binding double zinc finger protein; Actin-binding double zinc finger protein; Actin-binding LIM protein 1; Actin-binding LIM protein family member 1; DKFZp781D0148; FLJ14564; KIAA0059; LIM actin binding protein 1; LIMAB 1; LIMAB1; Limatin; RGD1565768; RP11-317F20.1.
詳細介紹：
規格:100ul
說 明 書100ul
研究領域細胞生物 神經生物學 信號轉導 細胞骨架 細胞外基質
抗體來源Rabbit
克隆類型Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
產品應用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88kDa
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ABLIM1
亞 型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資料：
產品介紹background:
The C. elegans protein Unc-115 mediates axon guidance by modulating the growth cone Actin cytoskeleton in response to signals received by growth cone receptors. The mammalian homolog of Unc-115 is the Actin-binding LIM protein family member 1 (ABLIM1, also designated Limatin). The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription
Function:
May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.
Subunit:
Binds F-actin. Interacts with ABRA.
Subcellular Location:
Cytoplasm. Cytoplasm > cytoskeleton. Associated with the cytoskeleton.
Tissue Specificity:
Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.
Similarity:
Contains 1 HP (headpiece) domain.
Contains 4 LIM zinc-binding domains.
